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Letter

Nature Genetics 38, 101–106 (1 January 2006) | doi:10.1038/ng1699

Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality

Ryuichi Ono , Kenji Nakamura , Kimiko Inoue , Mie Naruse , Takako Usami , Noriko Wakisaka-Saito , Toshiaki Hino , Rika Suzuki-Migishima , Narumi Ogonuki , Hiromi Miki , Takashi Kohda , Atsuo Ogura , Minesuke Yokoyama , Tomoko Kaneko-Ishino & Fumitoshi Ishino

By comparing mammalian genomes, we and others have identified actively transcribed Ty3/gypsy retrotransposon-derived genes with highly conserved DNA sequences and insertion sites. To elucidate the functions of evolutionarily conserved retrotransposon-derived genes in mammalian development, we produced mice that lack one of these genes, Peg10 (paternally expressed 10), which is a paternally expressed imprinted gene on mouse proximal chromosome 6.