Nature Genetics
Close windowclose window
Figure 1

Nature Genetics 38, 75 - 81 (2006)
Published online: 4 December 2005; | doi:10.1038/ng1697

A high-resolution survey of deletion polymorphism in the human genome

Donald F Conrad, T Daniel Andrews, Nigel P Carter, Matthew E Hurles & Jonathan K Pritchard

 
Fig 1 full size
Figure 1. Examples of four of the seven types of trio genotype configurations used in this analysis.
The true genetic state of each individual is depicted within his or her pedigree symbol. The called genotype, when it differs from the true genotype, is shown outside the pedigree symbol. The three upper configurations (A and C) all result in mendelian incompatibilities. We define 'Type I mendelian incompatibilities' as those that are compatible with a deletion transmitted from parent to child and 'Type II mendelian incompatibilities' as those that are incompatible with the deletion model. Key to figure: A: mendelian incompatibility, genotypes compatible with a deletion transmitted from the mother; C: mendelian incompatibility, genotypes incompatible with a transmitted deletion; E: no mendelian incompatibility, genotypes compatible with a deletion transmitted from the mother (but not the father); G: no mendelian incompatibility, genotypes incompatible with a transmitted deletion. Candidate deletion regions are runs of consecutive SNPs with at least two Type I mendelian incompatibilities and other SNPs that are compatible with a deletion; all the SNPs must suggest transmission from the same parent. See further details in Methods.

 
Next 
Close windowclose window
©2010 Nature Research | Privacy policy