Access

Letter

Nature Genetics 37, 958–963 (1 September 2005) | doi:10.1038/ng1626

A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M

Amom Ruhikanta Meetei , Annette L Medhurst , Chen Ling , Yutong Xue , Thiyam Ramsing Singh , Patrick Bier , Jurgen Steltenpool , Stacie Stone , Inderjeet Dokal , Christopher G Mathew , Maureen Hoatlin , Hans Joenje , Johan P de Winter & Weidong Wang

Fanconi anemia is a genetic disease characterized by genomic instability and cancer predisposition. Nine genes involved in Fanconi anemia have been identified; their products participate in a DNA damage–response network involving BRCA1 and BRCA2 (refs.