Access

Letter

Nature Genetics 37, 980–985 (1 September 2005) | doi:10.1038/ng1622

Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway

Jianbo Wang , Sharayne Mark , Xiaohui Zhang , Dong Qian , Seung-Jong Yoo , Kristen Radde-Gallwitz , Yanping Zhang , Xi Lin , Andres Collazo , Anthony Wynshaw-Boris & Ping Chen

The mammalian auditory sensory organ, the organ of Corti, consists of sensory hair cells with uniformly oriented stereocilia on the apical surfaces and has a distinct planar cell polarity (PCP) parallel to the sensory epithelium. It is not certain how this polarity is achieved during differentiation.