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Volume 37 Issue 9, September 2005

Cover art: Stochastic with Double Strand Ray-tracing capture of virtual installation by Constantin Polychronakos http://virtualbeing.ca

Volume 37 Issue 9

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Editorial

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Correspondence

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Meeting Report

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Book Review

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News & Views

  • How the Fanconi anemia chromosome stability pathway functions to cope with interstrand crosslinks and other DNA lesions has been elusive. The identification of two new Fanconi anemia–associated proteins with helicase motifs, FANCM and BRIP1 (also called FANCJ or BACH1), implicates the FANC nuclear core complex in recognizing or processing damaged DNA and the BRIP1 helicase as acting independently of this complex.

    • Larry H Thompson
    News & Views

  • The first replicating molecules were probably composed of RNA and undoubtedly small, limited in size by a self-destructing error rate. A new study shows that a relatively minor increase in replication fidelity may have had a large effect on the size, and hence complexity, of early replicators.

    • Edward C Holmes
    News & Views

  • A proportion of wild mice carry a variant region of chromosome 17 that results in severe transmission ratio distortion in males. The genetic basis of this distortion has long been enigmatic, but a recent study begins to disentangle it.

    • Mary F Lyon
    News & Views

  • Molecular noise, or random fluctuations in the levels of cellular components, arises spontaneously when there are small numbers of molecules and is transmitted to dependent processes. A new study shows how noise propagates through gene expression in yeast and shows that chromosomal position has a more central role than previously thought.

    • Johan Paulsson
    News & Views
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Brief Communication

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Article

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Letter

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