Nature Genetics
37, 923 - 924 (2005)
doi:10.1038/ng0905-923
On being the right sizeEdward C Holmes
Edward C. Holmes is in the Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA. ech15@psu.edu
The first replicating molecules were probably composed of RNA and undoubtedly small, limited in size by a self-destructing error rate. A new study shows that a relatively minor increase in replication fidelity may have had a large effect on the size, and hence complexity, of early replicators.
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