Unraveling the Fanconi anemia−DNA repair connection
Larry H Thompson
Larry H. Thompson is in the Biosciences Directorate, Biomedical Division, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, California 94551-0808, USA. Thompson14@llnl.gov
How the Fanconi anemia chromosome stability pathway functions to cope with interstrand crosslinks and other DNA lesions has been elusive. The identification of two new Fanconi anemia−associated proteins with helicase motifs, FANCM and BRIP1 (also called FANCJ or BACH1), implicates the FANC nuclear core complex in recognizing or processing damaged DNA and the BRIP1 helicase as acting independently of this complex.
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