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Letter

Nature Genetics 37, 873–877 (1 August 2005) | doi:10.1038/ng1606

Recombination of mitochondrial DNA in skeletal muscle of individuals with multiple mitochondrial DNA heteroplasmy

G|[aacute]|bor Zsurka , Yevgenia Kraytsberg , Tatiana Kudina , Cornelia Kornblum , Christian E Elger , Konstantin Khrapko & Wolfram S Kunz

Experimental evidence for human mitochondrial DNA (mtDNA) recombination was recently obtained in an individual with paternal inheritance of mtDNA and in an in vitro cell culture system. Whether mtDNA recombination is a common event in humans remained to be determined.