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Letter
Nature Genetics 37, 889–893 (1 August 2005) | doi:10.1038/ng1597
Inversion-induced disruption of the Hoxd cluster leads to the partition of regulatory landscapes
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Abstract
The developmental regulation of vertebrate Hox gene transcription relies on the interplay between local and long-range controls. To study this complex genomic organization, we designed a strategy combining meiotic and targeted recombinations to induce large chromosomal rearrangements in vivo without manipulating embryonic stem cells.
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