Nature Genetics
37, 794 - 795 (2005)
doi:10.1038/ng0805-794
Pharmacogenetics goes 3DHoward L McLeod
& Sharon Marsh
Howard L. McLeod and Sharon Marsh are at the Washington University School of Medicine, Departments of Medicine and Genetics and the Siteman Cancer Center, St. Louis, Missouri 63110, USA. hmcleod@im.wustl.edu
Applied genomics has focused on correlating clinical phenotypes with qualitative differences in DNA sequence such as variations in SNPs. A new study adds a third dimension, allele-specific copy-number differences, combining quantitative and qualitative approaches to understand the relationship between genetic variation and clinical outcome.
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