Flavius Martin is in the Department of Immunology and Vishva M. Dixit is in the Department of Molecular Oncology at Genentech, 1 DNA Way, South San Francisco, California 94080, USA. flavius@gene.com or dixit@gene.com
Primary immunodeficiencies, ranging from mild to very severe, comprise more than 50 different entities in which part of the body's immune system is missing or does not function properly. Two studies now report defects in the TNFR family member TACI associated with two forms of human immunodeficiency.
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