Microdeletion and IGF2 loss of imprinting in a cascade causing Beckwith-Wiedemann syndrome with Wilms' tumor

Dirk Prawitt^1, 6, Thorsten Enklaar^1, 6, Barbara Gärtner-Rupprecht¹, Christian Spangenberg¹, Ekkehart Lausch¹, Dirk Reutzel¹, Stephan Fees¹, Maria Korzon², Izabela Brozek³, Janusz Limon³, David E Housman⁴, Jerry Pelletier⁵ & Bernhard Zabel¹

¹  Children's Hospital, University of Mainz, Langenbeckstr. 1, D-55101 Mainz, Germany.

²  Medical University of Gdansk, Poland.

³  Department of Biology and Genetics, Medical University of Gdansk, Poland.

⁴  Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

⁵  Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, H3G 1Y6, Canada.

⁶  These authors contributed equally to this work.

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