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Letter

Nature Genetics 37, 739–744 (1 July 2005) | doi:10.1038/ng1592

TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function

Jochen Reiser , Krishna R Polu , Clemens C M|[ouml]|ller , Peter Kenlan , Mehmet M Altintas , Changli Wei , Christian Faul , Stephanie Herbert , Ivan Villegas , Carmen Avila-Casado , Mary McGee , Hikaru Sugimoto , Dennis Brown , Raghu Kalluri , Peter Mundel , Paula L Smith , David E Clapham & Martin R Pollak

Progressive kidney failure is a genetically and clinically heterogeneous group of disorders. Podocyte foot processes and the interposed glomerular slit diaphragm are essential components of the permeability barrier in the kidney.