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Letter
Nature Genetics 37, 771–776 (1 July 2005) | doi:10.1038/ng1591
Dynein mutations impair autophagic clearance of aggregate-prone proteins
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Abstract
Mutations that affect the dynein motor machinery are sufficient to cause motor neuron disease. It is not known why there are aggregates or inclusions in affected tissues in mice with such mutations and in most forms of human motor neuron disease.
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