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Letter
Nature Genetics 37, 756–760 (1 July 2005) | doi:10.1038/ng1588
The roles of MAD1, MAD2 and MAD3 in meiotic progression and the segregation of nonexchange chromosomes
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Abstract
Errors in meiotic chromosome segregation are the leading cause of spontaneous abortions and birth defects. In humans, chromosomes that fail to experience crossovers (or exchanges) are error-prone, more likely than exchange chromosomes to mis-segregate in meiosis.
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