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Letter
Nature Genetics 37, 745–749 (1 July 2005) | doi:10.1038/ng1586
Use of human tissue to assess the oncogenic activity of melanoma-associated mutations
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Abstract
Multiple genetic alterations occur in melanoma, a lethal skin malignancy of increasing incidence. These include mutations that activate Ras and two of its effector cascades, Raf and phosphoinositide 3-kinase (PI3K).
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