Bert L. Semler is in the Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, California 92697, USA. blsemler@uci.edu
A new study of dominant negative functions in cells infected by a positive-strand RNA virus detects an array of locus- and allele-specific effects. Exploiting subunit defects in multi-component complex assemblies provides a new approach to identifying targets for antiviral therapies that may inhibit the emergence of drug-resistant RNA virus populations.
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