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A new TRP to kidney disease

Autosomal dominant focal segmental glomerular sclerosis is a kidney disease that leads to progressive renal failure. Now, new studies show that mutations in the cation channel TRPC6 underlie this hereditary kidney disorder and establish a molecular link between TRPC6 and structural components of the glomerular slit diaphragm.

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Figure 1: Localization of TRPC6 in podocyte foot processes.

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Gudermann, T. A new TRP to kidney disease. Nat Genet 37, 663–664 (2005). https://doi.org/10.1038/ng0705-663

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