Thomas Gudermann is at the Institut für Pharmakologie und Toxikologie, Philipps-Universität Marburg, D-35033 Marburg, Germany. guderman@staff.uni-marburg.de
Autosomal dominant focal segmental glomerular sclerosis is a kidney disease that leads to progressive renal failure. Now, new studies show that mutations in the cation channel TRPC6 underlie this hereditary kidney disorder and establish a molecular link between TRPC6 and structural components of the glomerular slit diaphragm.
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