Autosomal dominant focal segmental glomerular sclerosis is a kidney disease that leads to progressive renal failure. Now, new studies show that mutations in the cation channel TRPC6 underlie this hereditary kidney disorder and establish a molecular link between TRPC6 and structural components of the glomerular slit diaphragm.
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References
Wolf, G. & Stahl, R.A. Lancet 362, 1746–1748 (2003).
Ly, J., Alexander, M. & Quaggin, S.E. Curr. Opin. Nephrol. Hypertens. 13, 299–305 (2004).
Reiser, J. et al. Nat. Genet. 37, 739–744 (2005).
Winn, M.P. et al. Science, published online 5 May 2005 (10.1126/science.1106215).
Clapham, D.E. Nature 426, 517–524 (2003).
Montell, C. Sci. STKE, re3 (2005).
Hofmann, T. et al. Nature 397, 259–263 (1999).
Konrad, M., Schlingmann, K.P., Gudermann, T. Am. J. Physiol. Renal Physiol. 286, F599–605 (2004).
Bach, G. Mol. Genet. Metab. 73, 197–203 (2001).
Wu, G. & Somlo, S. Mol. Genet. Metab. 69, 1–15 (2000).
Huber, T.B. & Benzing, T. Curr. Opin. Nephrol. Hypertens. 14, 211–216 (2005).
Pavenstädt, H., Kriz, W. & Kretzler, M. Physiol. Rev. 83, 253–307 (2003).
Welsh, D.G., Morielli, A.D., Nelson, M.T. & Brayden, J.E. Circ. Res. 90, 2448–2250 (2002).
Beech, D.J., Muraki, K. & Flemming, R. J. Physiol. 559, 685–706 (2004).
Huang, M., Gu, G., Ferguson, E.L. & Chalfie, M. Nature 378, 292–295 (1995).
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Gudermann, T. A new TRP to kidney disease. Nat Genet 37, 663–664 (2005). https://doi.org/10.1038/ng0705-663
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DOI: https://doi.org/10.1038/ng0705-663
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PLCE1 regulates the migration, proliferation, and differentiation of podocytes
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