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Volume 37 Issue 6, June 2005

Cover art: "Grail" by Birgit Woelker LEGO http://www.lego.com Photograph by Jeremy Green

Volume 37 Issue 6

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Editorial

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Commentary

  • The identification and investigation of sentinel cases has illuminated genetic discrimination in the US. Its occurrence impedes applications of biotechnology and is a primary focus of public policy activity at the federal level. Continued research and informed responses may make genetic nondiscrimination more likely.

    • Paul R Billings
    Commentary
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Video Review

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News & Views

  • Single-sperm genotyping has provided evidence for hot spots of locally intense recombination in humans. Previous efforts have shown that statistical methods can identify these hot spots as local deficits of linkage disequilibrium, but a report in this issue shows that some recombination hot spots leave no signature of reduced linkage disequilibrium.

    • Andrew G Clark
    News & Views

  • The restriction of herpesvirus by natural killer cells, initiated before the acquired immune response, illustrates the value of innate immune mechanisms for viral containment. Now, a new study shows that the activating natural killer cell receptor Ly49P and the major histocompatibility complex class I H-2Dk molecule act in concert to restrict mouse cytomegalovirus infection, identifying a new mechanism of host resistance.

    • Mary Carrington
    News & Views

  • Yeast's ability to produce ethanol in high concentrations has been exploited by humans for millennia. Two recent papers help us to understand the genetic changes that made this species so appealing to humans and the history of its domestication.

    • Meg Woolfit
    • Ken Wolfe
    News & Views
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Perspective

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Analysis

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Brief Communication

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Article

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Letter

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Technical Report

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Corrigendum

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Erratum

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Supplement

  • The microarray, in all its forms, has been an essential catalyst in promoting a genome-wide view of biology.

    Supplement
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