Cell microarrays and RNA interference chip away at gene function
Douglas B Wheeler, Anne E Carpenter
& David M Sabatini
Douglas B. Wheeler, Anne E. Carpenter and David M. Sabatini are at the Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology Department of Biology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.
The recent development of cell microarrays offers the potential to accelerate high-throughput functional genetic studies. The widespread use of RNA interference (RNAi) has prompted several groups to fabricate RNAi cell microarrays that make possible discrete, in-parallel transfection with thousands of RNAi reagents on a microarray slide. Though still a budding technology, RNAi cell microarrays promise to increase the efficiency, economy and ease of genome-wide RNAi screens in metazoan cells.
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