Nature Genetics
37, 607 - 612 (2005)
Published online: 1 May 2005; | doi:10.1038/ng1557
A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc diseaseShoji Seki, Yoshiharu Kawaguchi, Kazuhiro Chiba, Yasuo Mikami, Hideki Kizawa, Takeshi Oya, Futoshi Mio, Masaki Mori, Yoshinari Miyamoto, Ikuko Masuda, Tatsuhiko Tsunoda, Michihiro Kamata, Toshikazu Kubo, Yoshiaki Toyama, Tomoatsu Kimura, Yusuke Nakamura
& Shiro IkegawaSupplementary Fig. 1 (pdf 88K)
Real-time RT-PCR analysis of CILP mRNA in various human tissues and cell lines. Supplementary Fig. 2 (pdf 64K)
CILP expression in intervertebral disc tissue from LDD patients. Supplementary Fig. 3 (pdf 64K)
CILP expression in intervertebral disc tissues from a normal subject and an LDD patient (Schneiderman's grade 3). Supplementary Fig. 4 (pdf 76K)
Lack of NTPPHase activity in COS-7 cells expressing F-CILP. Supplementary Fig. 5 (pdf 76K)
Purified F-CILP containing p.I395 or p.T395, visualized by silver staining. Supplementary Fig. 6 (pdf 96K)
Effects of the LDD-associated SNP (p.I395T) in N-CILP on TGF- 1-induced expression of the aggrecan and type II collagen genes in rabbit nucleus pulposus cells. Supplementary Table 1 (pdf 64K)
Assessment of population stratification. Supplementary Table 2 (pdf 100K)
Haplotype analysis of CILP with lumbar disc herniation.
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