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Letter

Nature Genetics 37, 607–612 (1 June 2005) | doi:10.1038/ng1557

A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease

Shoji Seki , Yoshiharu Kawaguchi , Kazuhiro Chiba , Yasuo Mikami , Hideki Kizawa , Takeshi Oya , Futoshi Mio , Masaki Mori , Yoshinari Miyamoto , Ikuko Masuda , Tatsuhiko Tsunoda , Michihiro Kamata , Toshikazu Kubo , Yoshiaki Toyama , Tomoatsu Kimura , Yusuke Nakamura & Shiro Ikegawa

Lumbar disc disease (LDD) is caused by degeneration of intervertebral discs of the lumbar spine. One of the most common musculoskeletal disorders, LDD has strong genetic determinants.