Nature Genetics
37, 588 - 589 (2005)
Published online: 15 May 2005; | doi:10.1038/ng1575
Alternative splicing and gene duplication are inversely correlated evolutionary mechanismsNaama M Kopelman1, Doron Lancet1
& Itai Yanai1, 21
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel. 2
Present address: Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, 02138, USA.
Correspondence should be addressed to Itai Yanai yanai@mcb.harvard.eduGene duplication and alternative splicing are distinct evolutionary mechanisms that provide the raw material for new biological functions. We explored their relationships in human and mouse and found an inverse correlation between the size of a gene's family and its use of alternatively spliced isoforms. A cross-organism analysis suggests that selection for genome-wide genic proliferation might be interchangeably met by either evolutionary mechanism.
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