Andrew Clark is in the Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA. ac347@cornell.edu
Single-sperm genotyping has provided evidence for hot spots of locally intense recombination in humans. Previous efforts have shown that statistical methods can identify these hot spots as local deficits of linkage disequilibrium, but a report in this issue shows that some recombination hot spots leave no signature of reduced linkage disequilibrium.
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