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Volume 37 Issue 5, May 2005

Cover art: "Strange Attractors" by Eve Stockton. http://www.evestockton.com

Volume 37 Issue 5

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Editorial

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Correspondence

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Book Review

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News & Views

  • Inversin is a component of a poorly understood cilia-based mechanism responsible for specifying the left-right axis during development and for maintaining normal kidney architecture throughout life. A new study now suggests that inversin might act as a flow-regulated molecular switch between canonical and noncanonical Wnt pathways, providing insights into the mechanisms underlying cilia-based signaling processes.

    • Gregory G Germino
    News & Views

  • Epistasis analysis is a foundation in the analysis of genetic networks, but in complex or poorly defined processes, defining the phenotype can be an insurmountable hurdle. A new study shows that microarray expression profiles can be used as a 'phenotype' for epistasis analysis of the development of a multicellular organism, offering a potentially universal solution to this problem.

    • Timothy R Hughes
    News & Views

  • A microarray-based study of the nematode Caenorhabditis elegans offers a first glimpse of the effect of mutation accumulation on transcriptional variation. One major conclusion is that stabilizing selection must constrain the divergence of gene expression profiles in natural populations.

    • Greg Gibson
    News & Views

  • Maternal hypertension in pregnancy is a genetically complex condition originating in the placenta. Because of imprinting, only the maternal copy of the gene encoding STOX1 is expressed in invasive placental extravillous trophoblasts. Therefore, maternally inherited missense mutations affecting this putative DNA-binding protein predispose to preeclampsia, possibly by interfering with differentiation of the trophoblast cells.

    • Reynir Arngrímsson
    News & Views
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Brief Communication

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Article

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Letter

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Technical Report

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