Reynir Arngrímsson is in the Faculty of Medicine at the University of Iceland, Laeknadeildarhus, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland. reynirar@hi.is
Maternal hypertension in pregnancy is a genetically complex condition originating in the placenta. Because of imprinting, only the maternal copy of the gene encoding STOX1 is expressed in invasive placental extravillous trophoblasts. Therefore, maternally inherited missense mutations affecting this putative DNA-binding protein predispose to preeclampsia, possibly by interfering with differentiation of the trophoblast cells.
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