Timothy R. Hughes is at the Banting and Best Department of Medical Research at the University of Toronto, Toronto, Ontario M5G 1L6, Canada. t.hughes@utoronto.ca
Epistasis analysis is a foundation in the analysis of genetic networks, but in complex or poorly defined processes, defining the phenotype can be an insurmountable hurdle. A new study shows that microarray expression profiles can be used as a 'phenotype' for epistasis analysis of the development of a multicellular organism, offering a potentially universal solution to this problem.
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