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Brief Communication
Nature Genetics 37, 349–350 (1 April 2005) | doi:10.1038/ng1534
Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons
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Abstract
We report that Sir2 activation through increased sir-2.1 dosage or treatment with the sirtuin activator resveratrol specifically rescued early neuronal dysfunction phenotypes induced by mutant polyglutamines in transgenic Caenorhabditis elegans. These effects are dependent on daf-16 (Forkhead).
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