Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

The X chromosome: not just her brother's keeper

The X chromosome has traditionally been characterized as a conscientious sister to her derelict brother that is the Y. Beyond dutifully maintaining the family heritage, however, the X has developed its own unique identities. Now, the complete sequence of the human X allows us to appreciate its distinctiveness at an unprecedented resolution.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Ohno, S. Sex Chromosomes and Sex-Linked Genes (Springer, Berlin, 1967).

    Book  Google Scholar 

  2. Vallender, E.J. & Lahn, B.T. Bioessays 26, 159–169 (2004).

    Article  CAS  Google Scholar 

  3. Ross, M.T. et al. Nature 434, 325–337 (2005).

    Article  CAS  Google Scholar 

  4. Lahn, B.T. & Page, D.C. Science 286, 964–967 (1999).

    Article  CAS  Google Scholar 

  5. Lahn, B.T. & Page, D.C. Science 278, 675–680 (1997).

    Article  CAS  Google Scholar 

  6. Skaletsky, H. et al. Nature 423, 825–837 (2003).

    Article  CAS  Google Scholar 

  7. Carrel, L., Cottle, A.A., Goglin, K.C. & Willard, H.F. Proc. Natl. Acad. Sci. USA 96, 14440–14444 (1999).

    Article  CAS  Google Scholar 

  8. Jegalian, K. & Page, D.C. Nature 394, 776–780 (1998).

    Article  CAS  Google Scholar 

  9. Lyon, M.F. Cytogenet. Cell Genet. 80, 133–137 (1998).

    Article  CAS  Google Scholar 

  10. Rice, W.R. Evolution 38, 735–742 (1984).

    Article  Google Scholar 

  11. Saifi, G.M. & Chandra, H.S. Proc. R. Soc. Lond. B Biol. Sci. 266, 203–209 (1999).

    Article  CAS  Google Scholar 

  12. Wang, P.J., McCarrey, J.R., Yang, F. & Page, D.C. Nat. Genet. 27, 422–426 (2001).

    Article  Google Scholar 

  13. Khil, P.P., Smirnova, N.A., Romanienko, P.J. & Camerini-Otero, R.D. Nat. Genet. 36, 642–646 (2004).

    Article  CAS  Google Scholar 

  14. Wu, C.I. & Xu, E.Y. Trends Genet. 19, 243–247 (2003).

    Article  CAS  Google Scholar 

  15. Emerson, J.J., Kaessmann, H., Betran, E. & Long, M. Science 303, 537–540 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vallender, E., Pearson, N. & Lahn, B. The X chromosome: not just her brother's keeper. Nat Genet 37, 343–345 (2005). https://doi.org/10.1038/ng0405-343

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng0405-343

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing