Sir2 deacetylases are believed to promote the survival and longevity of organisms during times of adversity. A new study shows that activation of Sir2 by small molecules called sirtuin-activating compounds increases neuronal survival in two different models of Huntington disease, possibly opening new avenues for treatment.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Aggarwal, B.B. et al. Anticancer Res. 24, 2783–2840 (2004).
Parker, J. et al. Nat. Genet. 37, 349–350 (2005).
Sinclair, D.A. & Guarente, L. Cell 91, 1033–1042 (1997).
Kaeberlein, M., McVey, M. & Guarente, L. Genes Dev. 13, 2570–2580 (1999).
Tissenbaum, H.A. & Guarente, L. Nature 410, 227–230 (2001).
Rogina, B. & Helfand, S.L. Proc. Natl. Acad. Sci. USA 101, 15998–16003 (2004).
Wang, J. et al. FASEB J. (in the press).
Araki, T., Sasaki, Y. & Milbrandt, J. Science 305, 1010–1013 (2004).
Wood, J.G. et al. Nature 430, 686–689 (2004).
Picard, F. et al. Nature 429, 771–776 (2004).
Yeung, F. et al. EMBO J. 23, 2369–2380 (2004).
Walle, T., Hsieh, F., DeLegge, M.H., Oatis, J.E. Jr. & Walle, U.K. Drug Metab. Dispos. 32, 1377–1382 (2004).
Lamming, D.W., Wood, J.G. & Sinclair, D.A. Mol. Microbiol. 53, 1003–1009 (2004).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sinclair, D. Sirtuins for healthy neurons. Nat Genet 37, 339–340 (2005). https://doi.org/10.1038/ng0405-339
Issue Date:
DOI: https://doi.org/10.1038/ng0405-339
This article is cited by
-
Naringenin Ameliorates Chronic Sleep Deprivation‐Induced Pain via Sirtuin1 Inhibition
Neurochemical Research (2021)
-
Brain Activation of SIRT1: Role in Neuropathology
Molecular Neurobiology (2013)
-
Histone deacetylase inhibitors as therapeutics for polyglutamine disorders
Nature Reviews Neuroscience (2006)