Nature Genetics
37, 243 - 253 (2005)
Published online: 13 February 2005; | doi:10.1038/ng1522
Integrated transcriptional profiling and linkage analysis for identification of genes underlying diseaseNorbert Hubner, Caroline A Wallace, Heike Zimdahl, Enrico Petretto, Herbert Schulz, Fiona Maciver, Michael Mueller, Oliver Hummel, Jan Monti, Vaclav Zidek, Alena Musilova, Vladimir Kren, Helen Causton, Laurence Game, Gabriele Born, Sabine Schmidt, Anita Müller, Stuart A Cook, Theodore W Kurtz, John Whittaker, Michal Pravenec
& Timothy J AitmanSupplementary Fig. 1 (pdf 92K)
Validation of microarray gene expression data by RT-PCR. Supplementary Fig. 2 (pdf 120K)
Removal of redundancy resulting from linkage of expression values from an individual probe set to multiple adjacent markers. Supplementary Fig. 3 (pdf 196K)
Variation of number of defined cis-acting eQTLs with window-size. Supplementary Fig. 4 (pdf 72K)
Sequence analysis of Pik3c3 5'-upstream region, exons and exon-intron boundaries. Supplementary Table 1 (pdf 44K)
Number of linkages detected in fat and kidney data sets and estimated false discovery rate for different significance thresholds. Supplementary Table 2 (pdf 52K)
Number of linkages identified in common by eQTL Reaper and Wilcoxon-Mann-Whitney test. Supplementary Table 3 (pdf 40K)
Comparison of linkage results in RI strains using microarray data and quantitative real-time PCR. Supplementary Table 4 (xls 60K)
Physiological SHR QTLs mapped in previous genome screens. Supplementary Table 5a (xls 60K)
cis-acting eQTLs in fat and kidney tissue mapped at P<10-4. Supplementary Table 5b (xls 76K) Supplementary Table 6 (xls 60K)
trans-acting eQTLs (P<10-2). Supplementary Table 7 (pdf 64K)
Description of genetic map of 1,011 markers generated for the RI panel. Supplementary Table 8 (xls 264K)
Detailed information on the comparative analysis of rat and human blood pressure QTLs. Supplementary Note (pdf 68K)
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