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Letter

Nature Genetics 37, 295–299 (1 March 2005) | doi:10.1038/ng1523

Transcription control reprogramming in genetic backup circuits

Ran Kafri , Arren Bar-Even & Yitzhak Pilpel

A key question in molecular genetics is why severe mutations often do not result in a detectably abnormal phenotype. This robustness was partially ascribed to redundant paralogs that may provide backup for one another in case of mutation.