Joseph F. Costello is in The Brain Tumor Research Center, Dept. of Neurological Surgery, Comprehensive Cancer Center, University of California, San Francisco, California, USA. jcostello@cc.ucsf.edu
Proving that aberrant CpG island methylation has a functional role in human tumorigenesis is a chief goal in cancer epigenomics. A study now shows that a predictable mouse model of acute lymphocytic leukemia faithfully recapitulates the pattern, targets and frequency of aberrant methylation observed in its human counterpart and may soon allow the timing, and perhaps even the cause, of aberrant CpG island methylation to be investigated.
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