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Nature Genetics  37, 129 - 137 (2005)
Published online: 16 January 2005; | doi:10.1038/ng1508

A common inversion under selection in Europeans

Hreinn Stefansson, Agnar Helgason, Gudmar Thorleifsson, Valgerdur Steinthorsdottir, Gisli Masson, John Barnard, Adam Baker, Aslaug Jonasdottir, Andres Ingason, Vala G Gudnadottir, Natasa Desnica, Andrew Hicks, Arnaldur Gylfason, Daniel F Gudbjartsson, Gudrun M Jonsdottir, Jesus Sainz, Kari Agnarsson, Birgitta Birgisdottir, Shyamali Ghosh, Adalheidur Olafsdottir, Jean-Baptiste Cazier, Kristleifur Kristjansson, Michael L Frigge, Thorgeir E Thorgeirsson, Jeffrey R Gulcher, Augustine Kong & Kari Stefansson
 
Table 1 Relationship between number of children and H2 carrier status
CohortPredictorEstimateStandard errorP value
CombinedYear of birth-0.03400.00080.0000
Carrier of H20.07960.02590.0025
Sex0.23600.01900.0000
FemaleYear of birth-0.03310.00100.0000
Carrier of H20.09070.03380.0068
MaleYear of birth-0.03490.00120.0000
Carrier of H20.06790.03750.0719
Results from multiple regression analyses for a cohort of 16,959 females and 12,178 males born between 1925 and 1965, provided for the entire cohort and for the females and males analyzed separately. The regression uses weights that are inversely proportional to the probability that a person will be included in the regression. Standard errors and P values are empirically determined based on 10,000 simulations. The estimated effects presented here are statistical; they do not imply causation, as the results could be a consequence of the H2 chromosomes being correlated with some unknown functional variant(s).
 
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