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Letter
Nature Genetics  37, 177 - 181 (2005)
Published online: 23 January 2005; | doi:10.1038/ng1510

Admixture mapping for hypertension loci with genome-scan markers

Xiaofeng Zhu1, Amy Luke1, Richard S Cooper1, Tom Quertermous2, Craig Hanis3, Tom Mosley4, C Charles Gu5, Hua Tang6, Dabeeru C Rao5, Neil Risch7, 8 & Alan Weder9

1  Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, 2160 S. First Ave., Maywood, Illinois 60153, USA.

2  Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA.

3  Department of Genetics, University of Texas, Houston, Texas, USA.

4  Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, Mississippi, USA.

5  Division of Biostatistics, Washington University, St. Louis, Missouri, USA.

6  Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

7  Department of Genetics, Stanford University School of Medicine, Stanford, California 94305-5120, USA.

8  Division of Research, Kaiser Permanente, Oakland, California, USA.

9  Department of Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Correspondence should be addressed to Neil Risch risch@lahmed.stanford.edu
Identification of genetic variants that contribute to risk of hypertension is challenging. As a complement to linkage and candidate gene association studies, we carried out admixture mapping using genome-scan microsatellite markers among the African American participants in the US National Heart, Lung, and Blood Institute's Family Blood Pressure Program. This population was assumed to have experienced recent admixture from ancestral groups originating in Africa and Europe. We used a set of unrelated individuals from Nigeria to represent the African ancestral population and used the European Americans in the Family Blood Pressure Program to provide estimates of allele frequencies for the European ancestors. We genotyped a common set of 269 microsatellite markers in the three groups at the same laboratory. The distribution of marker location−specific African ancestry, based on multipoint analysis, was shifted upward in hypertensive cases versus normotensive controls, consistent with linkage to genes conferring susceptibility. This shift was largely due to a small number of loci, including five adjacent markers on chromosome 6q and two on chromosome 21q. These results suggest that chromosome 6q24 and 21q21 may contain genes influencing risk of hypertension in African Americans.


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Nature Genetics
ISSN: 1061-4036
EISSN: 1546-1718
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