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Letter
Nature Genetics 37, 1367–1371 (1 December 2005) | doi:10.1038/ng1685
Robust signals of coevolution of interacting residues in mammalian proteomes identified by phylogeny-aided structural analysis
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Abstract
The structure of a protein depends critically on the complex interactions among its amino acid residues. It has long been hypothesized that interacting residues might tend to coevolve, but it is not known whether such coevolution is a general phenomenon across the proteome.
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