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Aging (not so) gracefully

Although the correlation between maternal age and meiotic nondisjunction in human oocytes is widely recognized, the underlying molecular defects are largely unknown. New evidence from mice lacking SMC1β suggests that high levels of chromosome mis-segregation in older oocytes may be due in part to deterioration of meiotic sister-chromatid cohesion during aging.

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Figure 1: The consequences of gradual loss of cohesion in human oocytes during aging.

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Bickel, S. Aging (not so) gracefully. Nat Genet 37, 1303–1304 (2005). https://doi.org/10.1038/ng1205-1303

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