Nature Genetics 37, 1300 - 1302 (2005)
doi:10.1038/ng1205-1300
Gaining insight into PTPN22 and autoimmunityPeter K Gregersen
Peter K. Gregersen is at the Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York 11030, USA. peterg@nshs.edu
The protein tyrosine phosphatase PTPN22 (also called LYP) is the leading example of a genetic variant that confers risk of developing diverse human autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, autoimmune thyroid disease and systemic lupus. A new study now shows that the PTPN22 risk-associated variant, Trp620, results in a gain of PTPN22 phosphatase activity in T cells, opening up new avenues for exploring disease mechanisms.
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