A focus examining recent advances in mouse genetics and how to best exploit the vast tools and resources available in the mouse to advance our understanding of significant disease and human health issues
EMPReSS: standardized phenotype screens for functional annotation of the mouse genomep1155 The Eumorphia Consortium: A list of all members of The Eumorphia Consortium and their affiliations is given in Supplementary Note online.S.D.M. Brown, P. Chambon
& M. Hrabé de Angelis doi:10.1038/ng1105-1155 Full text|PDF
(64K)
|Supplementary Information
Focus on User's Guide to the Mouse Genetic variation in laboratory micepp1175 - 1180 Claire M Wade
& Mark J Daly Published online: 27 October 2005|doi:10.1038/ng1666 Abstract|Full text|PDF
(331K)
Focus on User's Guide to the Mouse The origins and uses of mouse outbred stockspp1181 - 1186 Ruth Chia, Francesca Achilli, Michael F W Festing
& Elizabeth M C Fisher Published online: 27 October 2005|doi:10.1038/ng1665 Abstract|Full text|PDF
(164K)
|Supplementary Information
Focus on User's Guide to the Mouse Current issues in mouse genome engineeringpp1187 - 1193 Stefan Glaser, Konstantinos Anastassiadis
& A Francis Stewart Published online: 27 October 2005|doi:10.1038/ng1668 Abstract|Full text|PDF
(226K)
Focus on User's Guide to the Mouse Strategies for dissecting epigenetic mechanisms in the mousepp1194 - 1200 Jesse Mager
& Marisa S Bartolomei Published online: 27 October 2005|doi:10.1038/ng1664 Abstract|Full text|PDF
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Focus on User's Guide to the Mouse Mice in the world of stem cell biologypp1201 - 1206 Geraldine Guasch
& Elaine Fuchs Published online: 27 October 2005|doi:10.1038/ng1667 Abstract|Full text|PDF
(401K)
Mutations in dynamin 2 cause dominant centronuclear myopathypp1207 - 1209 Marc Bitoun, Svetlana Maugenre, Pierre-Yves Jeannet, Emmanuelle Lacène, Xavier Ferrer, Pascal Laforêt, Jean-Jacques Martin, Jocelyn Laporte, Hanns Lochmüller, Alan H Beggs, Michel Fardeau, Bruno Eymard, Norma B Romero
& Pascale Guicheney Published online: 16 October 2005|doi:10.1038/ng1657 Abstract|Full text|PDF
(210K)
|Supplementary Information
A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in micepp1210 - 1212 Bruce J Herron, Rebecca A Liddell, April Parker, Sarah Grant, Jennifer Kinne, Jill K Fisher
& Linda D Siracusa Published online: 02 October 2005|doi:10.1038/ng1652 Abstract|Full text|PDF
(218K)
|Supplementary Information
Mutation of Vps54 causes motor neuron disease and defective spermiogenesis in the wobbler mousepp1213 - 1215 Thomas Schmitt-John, Carsten Drepper, Anke Mumann, Phillip Hahn, Melanie Kuhlmann, Cora Thiel, Martin Hafner, Andreas Lengeling, Peter Heimann, Julie M Jones, Miriam H Meisler
& Harald Jockusch Published online: 23 October 2005|doi:10.1038/ng1661 Abstract|Full text|PDF
(196K)
|Supplementary Information
Efficiency and power in genetic association studiespp1217 - 1223 Paul I W de Bakker, Roman Yelensky, Itsik Pe'er, Stacey B Gabriel, Mark J Daly
& David Altshuler Published online: 23 October 2005|doi:10.1038/ng1669 Abstract|Full text|PDF
(218K)
|Supplementary Information
Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traitspp1224 - 1233 Margarete Mehrabian, Hooman Allayee, Jirina Stockton, Pek Yee Lum, Thomas A Drake, Lawrence W Castellani, Michael Suh, Christopher Armour, Stephen Edwards, John Lamb, Aldons J Lusis
& Eric E Schadt Published online: 02 October 2005|doi:10.1038/ng1619 Abstract|Full text|PDF
(838K)
|Supplementary Information
Genetic variation in selenoprotein S influences inflammatory responsepp1234 - 1241 Joanne E Curran, Jeremy B M Jowett, Kate S Elliott, Yuan Gao, Kristi Gluschenko, Jianmin Wang, Dalia M Abel Azim, Guowen Cai, Michael C Mahaney, Anthony G Comuzzie, Thomas D Dyer, Ken R Walder, Paul Zimmet, Jean W MacCluer, Greg R Collier, Ahmed H Kissebah
& John Blangero Published online: 09 October 2005|doi:10.1038/ng1655 Abstract|Full text|PDF
(284K)
|Supplementary Information
Population structure, differential bias and genomic control in a large-scale, case-control association studypp1243 - 1246 David G Clayton, Neil M Walker, Deborah J Smyth, Rebecca Pask, Jason D Cooper, Lisa M Maier, Luc J Smink, Alex C Lam, Nigel R Ovington, Helen E Stevens, Sarah Nutland, Joanna M M Howson, Malek Faham, Martin Moorhead, Hywel B Jones, Matthew Falkowski, Paul Hardenbol, Thomas D Willis
& John A Todd Published online: 09 October 2005|doi:10.1038/ng1653 Abstract|Full text|PDF
(897K)
|Supplementary Information
Mutations in SECISBP2 result in abnormal thyroid hormone metabolismpp1247 - 1252 Alexandra M Dumitrescu, Xiao-Hui Liao, Mohamed S Y Abdullah, Joaquin Lado-Abeal, Fathia Abdul Majed, Lars C Moeller, Gerard Boran, Lutz Schomburg, Roy E Weiss
& Samuel Refetoff Published online: 16 October 2005|doi:10.1038/ng1654 Abstract|Full text|PDF
(356K)
Negative epistasis between the malaria-protective effects of +-thalassemia and the sickle cell traitpp1253 - 1257 Thomas N Williams, Tabitha W Mwangi, Sammy Wambua, Timothy E A Peto, David J Weatherall, Sunetra Gupta, Mario Recker, Bridget S Penman, Sophie Uyoga, Alex Macharia, Jedidah K Mwacharo, Robert W Snow
& Kevin Marsh Published online: 16 October 2005|doi:10.1038/ng1660 Abstract|Full text|PDF
(176K)
Monovalent cation leaks in human red cells caused by single amino-acid substitutions in the transport domain of the band 3 chloride-bicarbonate exchanger, AE1pp1258 - 1263 Lesley J Bruce, Hannah C Robinson, Hélène Guizouarn, Franck Borgese, Penny Harrison, May-Jean King, Jeroen S Goede, Suzanne E Coles, Daniel M Gore, Hans U Lutz, Romina Ficarella, D Mark Layton, Achille Iolascon, J Clive Ellory
& Gordon W Stewart Published online: 09 October 2005|doi:10.1038/ng1656 Abstract|Full text|PDF
(215K)
|Supplementary Information
Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cellspp1264 - 1269 Robert S Ohgami, Dean R Campagna, Eric L Greer, Brendan Antiochos, Alice McDonald, Jing Chen, John J Sharp, Yuko Fujiwara, Jane E Barker
& Mark D Fleming Published online: 16 October 2005|doi:10.1038/ng1658 Abstract|Full text|PDF
(419K)
|Supplementary Information
A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) micepp1270 - 1273 Jackie E Lim, Ou Jin, Carolyn Bennett, Kelly Morgan, Fudi Wang, Cameron C Trenor III, Mark D Fleming
& Nancy C Andrews Published online: 16 October 2005|doi:10.1038/ng1659 Abstract|Full text|PDF
(234K)
|Supplementary Information
Global hypomethylation of the genome in XX embryonic stem cellspp1274 - 1279 Ilona Zvetkova, Anwyn Apedaile, Bernard Ramsahoye, Jacqueline E Mermoud, Lucy A Crompton, Rosalind John, Robert Feil
& Neil Brockdorff Published online: 23 October 2005|doi:10.1038/ng1663 Abstract|Full text|PDF
(686K)
|Supplementary Information
Second-generation shRNA libraries covering the mouse and human genomespp1281 - 1288 Jose M Silva, Mamie Z Li, Ken Chang, Wei Ge, Michael C Golding, Richard J Rickles, Despina Siolas, Guang Hu, Patrick J Paddison, Michael R Schlabach, Nihar Sheth, Jeff Bradshaw, Julia Burchard, Amit Kulkarni, Guy Cavet, Ravi Sachidanandam, W Richard McCombie, Michele A Cleary, Stephen J Elledge
& Gregory J Hannon Published online: 02 October 2005|doi:10.1038/ng1650 Abstract|Full text|PDF
(394K)
|Supplementary Information See also:News and Views by Cullen|Technical Report by Dickins et al.
Probing tumor phenotypes using stable and regulated synthetic microRNA precursorspp1289 - 1295 Ross A Dickins, Michael T Hemann, Jack T Zilfou, David R Simpson, Ingrid Ibarra, Gregory J Hannon
& Scott W Lowe Published online: 02 October 2005|doi:10.1038/ng1651 Abstract|Full text|PDF
(514K)
See also:News and Views by Cullen|Technical Report by Silva et al.
Addendum: The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemiap1296 O Levran, C Attwooll, R T Henry, K L Milton, K Neveling, P Rio, S D Batish, R Kalb, E Velleuer, S Barral, J Ott, J Petrini, D Schindler, H Hanenberg
& A D Auerbach doi:10.1038/ng1105-1296 Full text|PDF
(42K)
mann, Phillip Hahn, Melanie Kuhlmann, Cora Thiel, Martin Hafner, Andreas Lengeling, Peter Heimann, Julie M Jones, Miriam H Meisler
& Harald Jockusch
+-thalassemia and the sickle cell trait
