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Letter
Nature Genetics 37, 1253–1257 (1 November 2005) | doi:10.1038/ng1660
Negative epistasis between the malaria-protective effects of |[alpha]|+-thalassemia and the sickle cell trait
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Abstract
The hemoglobinopathies, disorders of hemoglobin structure and production, protect against death from malaria. In sub-Saharan Africa, two such conditions occur at particularly high frequencies: presence of the structural variant hemoglobin S and α+-thalassemia, a condition characterized by reduced production of the normal α-globin component of hemoglobin.
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