Nature Genetics 37, 1181 - 1186 (2005)
Published online: 27 October 2005; | doi:10.1038/ng1665
The origins and uses of mouse outbred stocksRuth Chia1, Francesca Achilli1, Michael F W Festing2
& Elizabeth M C Fisher11
Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, UK. 2
c/o MRC Toxicology Unit, Hodgkin Building, University of Leicester, PO Box 138, Lancaster Road, Leicester LE1 9HN, UK.
Correspondence should be addressed to Elizabeth M C Fisher e.fisher@prion.ucl.ac.uk Outbred mouse stocks, often used in genetics, toxicology and pharmacology research, have been generated in rather haphazard ways. Understanding the characteristics of these stocks and their advantages and disadvantages is important for experimental design. In many studies these mice are used inappropriately, wasting animals' lives and resources on suboptimal experiments. Recently, however, researchers from the field of complex trait analysis have capitalized on the genetics of outbred stocks to refine the identification of quantitative trait loci. Here we assess the most widely used outbred stocks of mice and present guidelines for their use.
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