Bryan R. Cullen is in the Center for Virology and Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA. culle002@mc.duke.edu
Although RNA interference has become a useful genetic technique, effective and stable knock-down of vertebrate genes remains a challenge, especially in vivo. A new approach, which uses RNA polymerase II to generate small interfering RNAs, not only seems to be more effective than previous approaches but also allows tightly regulated RNA interference in culture and in vivo.
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