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Letter

Nature Genetics 37, 1108–1112 (1 October 2005) | doi:10.1038/ng1647

A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis

Matthew R Lincoln , Alexandre Montpetit , M Zameel Cader , Janna Saarela , David A Dyment , Milvi Tiislar , Vincent Ferretti , Pentti J Tienari , A Dessa Sadovnick , Leena Peltonen , George C Ebers & Thomas J Hudson

Genetic susceptibility to multiple sclerosis is associated with genes of the major histocompatibility complex (MHC), particularly HLA-DRB1 and HLA-DQB1 (ref. 1).