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Letter
Nature Genetics 37, 1125–1129 (1 October 2005) | doi:10.1038/ng1632
Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster
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Abstract
Loss of cell polarity and cancer are tightly correlated, but proof for a causative relationship has remained elusive. In stem cells, loss of polarity and impairment of asymmetric cell division could alter cell fates and thereby render daughter cells unable to respond to the mechanisms that control proliferation.
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