A new study of mice lacking Prox1, a gene required for the formation of lymphatic endothelial cells, unveils a link between lymph fluid and fat deposition. These findings bring the lymphatic vascular system into the focus of obesity research.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
SVF-derived extracellular vesicles carry characteristic miRNAs in lipedema
Scientific Reports Open Access 29 April 2020
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Harvey, N. et al. Nat. Genet. 37, 1072–1081 (2005).
Asellius, G. in De Lacteibus sive lacteis venis Quarto Vasorum mesaroicum genere novo invente Gasp (Mediolani, Milan, 1627).
Alitalo, K. & Carmeliet, P. Cancer Cell 1, 219–227 (2002).
Ny, A. et al. Nat. Med. 11, 998–1004 (2005).
Wigle, J.T. et al. EMBO J. 21, 1505–1513 (2002).
Wigle, J.T. & Oliver, G. Cell 98, 769–778 (1999).
Fernyhough, M.E. et al. Tissue Cell 37, 335–338 (2005).
Rosen, E.D. Ann. NY Acad. Sci. 979, 143–58 (2002).
Kadowaki, T. & Yamauchi, T. Endocr. Rev. 26, 439–451 (2005).
Bagheri, S., Ohlin, K., Olsson, G. & Brorson, H. Lymphat. Res. Biol. 3, 66–80 (2005).
Nougues, J., Reyne, Y. & Dulor, J.P. Int. J. Obes. 12, 321–333 (1988).
Karkkainen, M.J. et al. Proc. Natl. Acad. Sci. USA 98, 12677–12682 (2001).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schneider, M., Conway, E. & Carmeliet, P. Lymph makes you fat. Nat Genet 37, 1023–1024 (2005). https://doi.org/10.1038/ng1005-1023
Issue Date:
DOI: https://doi.org/10.1038/ng1005-1023
This article is cited by
-
Non-contrast magnetic resonance lymphography (NCMRL) in cancer-related secondary lymphedema: acquisition technique and imaging findings
La radiologia medica (2021)
-
SVF-derived extracellular vesicles carry characteristic miRNAs in lipedema
Scientific Reports (2020)
-
Rare adipose disorders (RADs) masquerading as obesity
Acta Pharmacologica Sinica (2012)