Nature Genetics
37, 1113 - 1118 (2005)
Published online: 25 September 2005; | doi:10.1038/ng1646
A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibilityDavid Reich1, 2, Nick Patterson2, Philip L De Jager2, 3, 4, Gavin J McDonald1, 2, Alicja Waliszewska2, 3, 4, Arti Tandon1, 2, Robin R Lincoln5, Cari DeLoa5, Scott A Fruhan1, 2, 3, 4, Philippe Cabre6, Odile Bera6, Gilbert Semana7, M Ann Kelly8, David A Francis8, Kristin Ardlie9, Omar Khan10, Bruce A C Cree5, Stephen L Hauser5, Jorge R Oksenberg5
& David A Hafler2, 3, 41
Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA. 2
Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. 3
Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA. 4
Laboratory of Molecular Immunology, Center for Neurologic Disease, Brigham and Women's Hospital, Boston, Massachusetts, USA. 5
Department of Neurology, University of California, San Francisco, California, USA. 6
Clinique Neurologique, L'Hôpital Quitman, Fort-de-France, France. 7
Laboratoire Universitaire d'Immunologie, University de Rennes 1 and Etablissement Français du Sang Bretagne, Rennes, France. 8
Department of Medicine, Division of Medical Sciences, University Hospital Birmingham, UK. 9
Genomics Collaborative, Division of SeraCare Life Sciences Inc, Cambridge, Massachusetts, USA. 10
Multiple Sclerosis Center, Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA.
Correspondence should be addressed to David Reich reich@receptor.med.harvard.edu Multiple sclerosis is a common disease with proven heritability, but, despite large-scale attempts, no underlying risk genes have been identified. Traditional linkage scans have so far identified only one risk haplotype for multiple sclerosis (at HLA on chromosome 6), which explains only a fraction of the increased risk to siblings. Association scans such as admixture mapping have much more power, in principle, to find the weak factors that must explain most of the disease risk. We describe here the first high-powered admixture scan, focusing on 605 African American cases and 1,043 African American controls, and report a locus on chromosome 1 that is significantly associated with multiple sclerosis.
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