David W. Threadgill is in the Department of Genetics and the Lineberger Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA. dwt@med.unc.edu
Cancer metastasis has historically been viewed in the context of the mutational spectra arising during development of the primary cancer. The identification of a new modifier of cancer metastasis efficiency in mice provides experimental support for a predisposition model in which metastatic potential is viewed as a heritable trait influenced by host genetic polymorphisms.
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