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Out with the old, in with the new

Transcription-coupled nucleosome turnover provides an opportunity to incorporate new nucleosomes at active genes. Swapping nucleosomes that contain silencing marks with those that are more permissive for transcription may provide a mechanism for remembering the activity state of a gene through the cell cycle.

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Figure 1: Replication-independent deposition of histone H3.3.

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Lieb, J. Out with the old, in with the new. Nat Genet 37, 1024–1025 (2005). https://doi.org/10.1038/ng1005-1024

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