Nature Genetics
37, 84 - 89 (2004)
Published online: 19 December 2004; | doi:10.1038/ng1488
A single-nucleotide polymorphism tagging set for human drug metabolism and transportKourosh R Ahmadi, Mike E Weale, Zhengyu Y Xue, Nicole Soranzo, David P Yarnall, James D Briley, Yuka Maruyama, Mikiro Kobayashi, Nicholas W Wood, Nigel K Spurr, Daniel K Burns, Allen D Roses, Ann M Saunders
& David B GoldsteinSupplementary Fig. 1 (pdf 100K)
Distribution of minor allele frequencies and marker characteristics for the 55 genes. Supplementary Fig. 2 (pdf 72K)
Number of high-LD blocks and percent sequence belonging to high-LD blocks, as a function of block size in the CEPH and the Japanese. Supplementary Fig. 3 (pdf 92K)
Initial sample size and performance of tags selected in the full data set. Supplementary Fig. 4 (pdf 144K)
Initial sample size and performance of tags selected in the reduced data set (SNPs excluded with MAF < 0.05). Supplementary Fig. 5 (pdf 92K)
Comparison of results obtained through bootstrapping (sampling with replacement) and splitting (sampling without replacement). Supplementary Fig. 6 (pdf 160K)
SNP-by-SNP performance of the tags selected for each gene or gene complex (SNPs excluded with MAF < 0.05) in the CEPH. Supplementary Fig. 7 (pdf 96K)
SNP-by-SNP performance of the tags selected for each gene or gene complex (SNPs excluded with MAF < 0.05) in the Japanese. Supplementary Fig. 8 (pdf 68K)
Plot of the minor allele frequency (MAF) of 69 SNPs in 238 individuals from Aberdeen against 64 CEPH individuals. Supplementary Fig. 9 (pdf 88K)
The effect of initial genotyping density on tag performance. Supplementary Table 1 (xls 68K)
Summary information on all ADME gene clusters. Supplementary Table 2 (xls 160K)
Summary information of all 904 SNPs studied as part of this study. Supplementary Table 3 (pdf 72K)
The tagging SNPs for the CEPH sample. Supplementary Table 4 (pdf 72K)
The tagging SNPs for the Japanese sample. Supplementary Table 5 (pdf 76K)
The cosmopolitan tagging SNP set. Supplementary Table 6 (pdf 160K)
List of the 9 functional variants included in the analyses. Supplementary Table 7 (pdf 88K)
List of the variants genotyped in 238 individuals from Aberdeen for direct evaluation of the utility of tSNPs. Supplementary Table 8 (pdf 52K)
The list of genes organized into clusters to quantify the effect of long-range LD. Supplementary Table 9 (pdf 48K)
The list of genes used in the density experiments.
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