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Letter
Nature Genetics 37, 77–83 (1 January 2005) | doi:10.1038/ng1489
Modular epistasis in yeast metabolism
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Abstract
Epistatic interactions, manifested in the effects of mutations on the phenotypes caused by other mutations, may help uncover the functional organization of complex biological networks. Here, we studied system-level epistatic interactions by computing growth phenotypes of all single and double knockouts of 890 metabolic genes in Saccharomyces cerevisiae, using the framework of flux balance analysis.
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